HIV patients should not lose their hope because researchers revealed an antibody combination which can combat the HIV. The treatment combines three antibodies. Researchers at the Rockefeller University have conducted a new study, and they explained that the dangerous virus eventually loses the fight and dies after this antibody combination is used.
The HIV can mutate, a process which was difficult to be annihilated. Once the virus enters the body, it will block all types of immune therapies, and it will remain in the body forever. The newly developed research was published in the Science Translational Medicine magazine. Many persons who have AIDS have been using the antiretroviral treatment which was able to bring significant help.
Without this drug treatment, the body of the infected person will slowly become unable to control the HIV-virus. Unfortunately, when using ART as an HIV treatment, failure rates are pretty high because the virus manages somehow to mutate and escape the immune system. Nevertheless, the new treatment which combines three antibodies is prone to capture the virus and eliminate it.
During the experiments, specialists used a mixture of three antibodies to administrate it to mice infected with HIV. The results were unbelievable. The power of this treatment annihilated the virus, ultimately destroying it. After a person contracts the HIV, his or her immune system experiences failure. However, there exist some patients who despite the fact that they are infected, they manage to destroy the virus by neutralizing antibodies. These persons are known as elite controllers.
The study was conducted at Michel C. Nussenzweig’s Laboratory, a professor at The Rockefeller University and the head of the Laboratory of Molecular Immunology. Researchers have made an antibody cocktail containing BG1, NC37, and BG18. This mixture was administrated to HIV-infected mice. The antibodies attach to an epitope, a part of the HIV, and sustain each other until they manage to destroy the HIV.
Natalia Freund, the main author of the study, stated that some people infected with HIV could produce these antibodies, but, unfortunately, they are not resistant enough to kill the dangerous virus. Freund decided to test and compare the link between the virus and the antibodies to an arms race. Nevertheless, mutations help the virus to become immune to the antibodies and further evolve.
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